RECENT AND NOVEL Formulations AGAINST PERIODONTAL DISEASE
DOXYCYCLINE HYDROCHLORIDE GEL FOR LDD
Doxycycline reduces pathogenic bacteria, modulate inflammatory responses and improve clinical parameters like probing depth and attachment levels. Studies suggest that when combined with traditional mechanical treatment, doxycycline gel can enhance patient outcomes.
Noni (Morinda citrifolia) extract for LDD
Noni extract is packed with antioxidants, including iridoids, that may provide numerous health benefits. It can reduce cellular damage — particularly from tobacco smoke and offers various anti-inflammatory and antioxidant benefits.
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Polyvinyl alcohol (PVA)- Polyvinylpyrrolidone (PVP) extract
Polyvinyl alcohol (PVA)- Polyvinylpyrrolidone (PVP) extract
Polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) can be used in treating periodontitis, as it can act as a carrier for various therapeutic agents due to its low toxicity, biocompatibility and biodegradability.
Moringa oleifera ointment
Polyvinyl alcohol (PVA)- Polyvinylpyrrolidone (PVP) extract
Moringa has compounds that help reduce inflammation. It has a high content of antioxidants, which can help protect against oxidative stress and chronic diseases.
Spirulina extract for LDD
Indocyanine green (ICG) gel
Spirulina is a nutrient-dense blue-green algae that has numerous health benefits. The main active compound in spirulina, phycocyanin, boasts strong antioxidant and anti-inflammatory effects.
Indocyanine green (ICG) gel
Indocyanine green (ICG) gel
Indocyanine green (ICG) is a cyanine dye with a peak spectral absorption at about 800 nm. ICG acts as a photosensitizer, which means it produces reactive oxygen species (ROS) when exposed to this wavelength of light.
1% Metformin gel
Use of metformin gel in different concentrations (0.5–1%) for the treatment of periodontitis has been shown to have positive effects in multiple clinical studies.
Moringa oleifera LDD Gel
Moringa-based compounds are associated with a significant reduction in gingivitis and plaque.
Quaternary Ammonium Silane Irrigant Solution
Quaternary Ammonium Silane Irrigant Solution
A potent chemical irrigant to eliminate the biofilm from dentin surface.
Doxycycline Coated Collagen Discs
Doxycycline Coated Collagen Discs
Quaternary Ammonium Silane Irrigant Solution
Ideal for LDD studies, research purposes and for therapeutic applications.
Titanium foil for GBR
Doxycycline Coated Collagen Discs
Titanium foil for GBR
Titanium foil maintains its shape, creating a stable barrier between the membrane and the bone defect. This feature ensures proper space for bone regeneration.
Mangosteen based gel
Doxycycline Coated Collagen Discs
Titanium foil for GBR
Manosteen increases osteocalcin and collagen1 expressions, as producers of osteoblasts, thereby accelerating alveolar bone regeneration.
Bentonite impregnated Bone Graft
Strontium Chloride impregnated Collagen Membrane
Bentonite is a strong inducer of collagen synthesis, cell proliferation and angiogenesis.
Strontium Chloride impregnated Collagen Membrane
Strontium Chloride impregnated Collagen Membrane
Strontium generates a favorable immune environment and promotes early angiogenesis at the implantation site.
FGF-2 in Collagen Sponge for Socket Preservation Protocols.
Insulin-like growth factor (IGF) Impregnated fibers for Local Drug Delivery
Growth factors such as FGF-2 with Collagen for alveolar ridge preservation are promising for future daily clinical practice.
Insulin-like growth factor (IGF) Impregnated fibers for Local Drug Delivery
Insulin-like growth factor (IGF) Impregnated fibers for Local Drug Delivery
Insulin-like growth factor (IGF) is a hormone that helps promote normal bone and tissue growth and development.
1% Metformin Chip
CHLORHEXIDINE CHIP FOR ROOT CANAL DISINFECTION
Metformin exerts antibacterial activity against pathogens linked to periodontitis such as Porphyromonas gingivalis and Tannerella forsythia. It also inhibits the expression of inflammatory cytokines such as interleukin-6, interleukin-1β and tumor necrosis factor alpha in human gingival fibroblasts activated by Porphyromonas gingivalis.
CHLORHEXIDINE CHIP FOR ROOT CANAL DISINFECTION
CHLORHEXIDINE CHIP FOR ROOT CANAL DISINFECTION
Chip designed to be placed in the pulp-chamber for controlled release of Chlorhexidine.
Mangosteen (Garcinia mangostana) peel extract
Mangosteen peel extract for bone regeneration. Designed to be used as a standalone material or in conjunction with bone grafts.
Titanium granules based bone-graft
The proposed graft consists of irregular porous granules of commercially pure titanium. The porous properties may lead to ingrowth of newly formed bone as titanium results in the potent activation of the intrinsic coagulation system and the subsequent release of growth factors from platelets
Portulaca badamica 5% gel
Made from 750 gms of aerial parts of Portulaca badamica, dried and grounded. Picture shows the stock solution and the gel made from it for LDD.
Stevia rebaudiana bertoni based LDD agent
Stevia rebaudiana bertoni is a natural non-caloric sweetener and has an anti-plaque effect because of its ability in decreasing the formation of bacterial insoluble polymers. It significantly decreases the production of TNF-R and IL-1a and slightly decreases the production of NO in cells stimulated with LPS. These characteristics can be used in the treatment of periodontal diseases.
Low cost chlorhexidine (CHX) chip for intra-pocket delivery
Well known in periodontology, CHX acts against most of the putative periodontopathic organisms.
Ursodeoxycholic acid (UDCA) based LDD gel
UDCA is known to exert antioxidant, anti-inflammatory and anti-apoptotic effects. These properties can be used to reduce the progression and severity of periodontal disease.